Bioinformatics and Biocomputing
Zhijun Wu, Iowa State University
Professor, Department of Mathematics
November 03 2008 10:00 am
Fred Frey Room 307
Biological systems are complex information systems, with their information, in complex genetic forms, passed from generation to generation, shared in families of species, and most importantly, coded to produce the ingredients necessary to make the diverse forms of life and to conduct complicated biological processes. Since the discovery of the double helical structure of DNA and hence the secrete of genetic inheritance of life in 1953, biology has entered a new era of research on how biological systems have ever evolved at molecular genetic levels and how genetic information has been coded, stored, and processed at various stages of life. Later, with the completion of the human genome project in 2000, the field of bioinformatics and computational biology has emerged and rapidly developed, as a result of the urgent need for the access to the enormous amount of data generated from all the genomic research projects and also as a result of the recognition of modern biological science as an information science, where informatics and computation have played crucial roles. Indeed, bioinformatics and computational biology have become important and sometimes, even indispensable tools and made great impacts in many fundamental research areas of biology, ranging from genomic sequencing to protein modeling, from gene annotation to protein functional prediction, from structural genomics studies to microarray data analysis, from gene regulatory network analysis to metabolic pathway identification, from drug design to cancer modeling, etc. In this talk, I will give a brief introduction to the field of bioinformatics and computational biology, with a focus on sequence analysis, structural computing, and systems modeling and in particular, on their biological motivations, the related computational problems, the general approaches to the problems, and the mathematical and computational challenges.